Tipranavir in the Protease Inhibitors Arena
نویسندگان
چکیده
منابع مشابه
Tipranavir in the Protease Inhibitors Arena
Highly active antiretroviral therapy (HAART) has become the standard for treating HIV infection. HIV protease inhibitors (PIs) have been used as amajor component of theHAART regimens over the past 10 years, along with nucleoside and non-nucleoside reverse transcriptase inhibitors. The introduction of these regimens resulted in an appreciable decline in morbidity and mortality due to HIV infecti...
متن کاملImpact of first-line protease inhibitors on predicted resistance to tipranavir in HIV-1-infected patients with virological failure
BACKGROUND Tipranavir (TPV) is a recently approved nonpeptidic protease inhibitor (PI) of HIV-1 and has been indicated for those infected with PIs-resistant HIV-1. However, in clinical practice, whether the HIV-1 from the patients with virological failure to the regimens containing first-line PIs remains susceptible to TPV/r may be questionable. METHODS To assess the resistance levels to TPV ...
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Background and Aim: Advent of COVID-19 attracted the attentions of researchers to develop drugs for its treatment. Besides efforts on developing new drugs, screening available drugs for efficacy on COVID-19 could be an urgent action of initiating its pharmacotherapy. In this study, efficacy of HIV protease inhibitors on COVID-19 protease has been examined. Methods: Molecular docking based scree...
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ژورنال
عنوان ژورنال: Drugs in R&D
سال: 2011
ISSN: 1174-5886,1179-6901
DOI: 10.2165/11594570-000000000-00000